Compartmental Modeling for the Neophyte: An Application of Berkeley Madonna

Compartmental modeling serves as a necessary framework in many fields, especially biomathematics and ecology. This article introduces readers to a user-friendly approach to constructing compartmental models and solving the resulting systems of differential equations to simulate real-world applications. The platform used is Berkeley Madonna, a software package that has an intuitive graphical interface which empowers users—even those with limited mathematical and programming backgrounds—to focus on modeling concepts rather than mathematical or programming intricacies. This makes Berkeley Madonna an ideal platform for students, educators, and researchers

Factors controlling the distribution of seabirds: Winter-summer heterogeneity in the distribution of adélie penguin populations

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A β‑Peptide Agonist of the GLP‑1 Receptor, a Class B GPCR

Previous work has shown that certain β(3)-peptides can effectively mimic the side chain display of an α-helix and inhibit interactions between proteins, both in vitro and in cultured cells. Here we describe a β(3)-peptide analog of GLP-1, CC-3(Act), that interacts with the GLP-1R extracellular domain (nGLP-1R) in vitro in a manner that competes with exendin-4 and induces GLP-1R-dependent cAMP signaling in cultured CHO-K1 cells expressing GLP-1R

A β‑Peptide Agonist of the GLP‑1 Receptor, a Class B GPCR

Previous work has shown that certain β³-peptides can effectively mimic the side chain display of an α-helix and inhibit interactions between proteins, both <i>in vitro</i> and in cultured cells. Here we describe a β³-peptide analog of GLP-1, CC-3^Act, that interacts with the GLP-1R extracellular domain (nGLP-1R) <i>in vitro</i> in a manner that competes with exendin-4 and induces GLP-1R-dependent cAMP signaling in cultured CHO-K1 cells expressing GLP-1R